aMoon Explorer
Powered by aMoon and M Ventures, the 2nd cohort of the Explorer program targets translational breakthrough academic research in three areas poised for major transformation - longevity, infertility and genomic editing
JOIN THE JOURNEY
aMoon Explorer program aims to harness pioneering scientific research to transform the way we diagnose, treat and cure diseases.
For the program’s second cohort, aMoon partnered with M-Ventures to bring our cumulative expertise, global networks, financial capabilities, and development tools to translate revolutionary ideas to practice.
We are searching for highly-disruptive, high-impact proposals for sponsored translational breakthrough academic research in three areas: longevity, infertility and genomic editing.
THE PROGRAM
Areas of focus
For the program’s second cohort, aMoon partnered with M-Ventures to bring our cumulative expertise, global networks, financial capabilities, and development tools to translate revolutionary ideas to practice.
We are searching for highly-disruptive, high-impact proposals for sponsored translational breakthrough academic research in three areas: longevity, infertility and genomic editing.
WHAT ARE WE SOLVING FOR?
Areas of focus
For the program’s second cohort, aMoon partnered with M-Ventures to bring our cumulative expertise, global networks, financial capabilities, and development tools to translate revolutionary ideas to practice.
We are searching for highly-disruptive, high-impact proposals for sponsored translational breakthrough academic research in three areas: longevity, infertility and genomic editing.
WHAT ARE WE SOLVING FOR?
02
Emerging diagnostic and therapeutic strategies for female and male infertility
Infertility is a global issue affecting 15% of reproductive-aged couples worldwide according to the WHO. Infertility has many potential causes and involves the male and/or female reproductive systems. The science of fertility addresses prevention, diagnosis and treatment of the condition, targeting both primary infertility (the inability to generate a first pregnancy) and secondary infertility (the inability to generate a second pregnancy).
WHAT ARE WE SOLVING FOR?
• Novel mechanisms of action to treat inflammation-induced infertility
• Novel mechanisms of action to address ovarian aging
• Novel technologies to assess egg quality and predict implantation outcomes
• Novel mechanisms of action to treat endometriosis
• New therapeutic approaches for male infertility
• Treatments for infertility based on the alteration of reproductive tract microbiome
• Novel minimally invasive IVF technologies
Emerging therapeutic approaches promoting Longevity
The field of longevity is not limited to extending lifespan, but instead aims to extend health span. This notion has garnered increasing interest from the scientific, pharmaceutical and biotech communities in the last decade. Although our bodies are inherently equipped with regenerative and healing functions, these wear off or completely shut down with age, leading to onset of diseases ranging from neurodegeneration to cardio-metabolic and mental disorders.
01
WHAT ARE WE SOLVING FOR?
• New anti-senescence therapies - (e.g., immunomodulators or senomorphics, rather than senolytic)
• Novel Biomarkers for biological age of cells (e.g., biomarkers applicable to a longevity therapeutics
• Epigenetic profiling for age related indications and potential applications
• Stem cell therapy for age related indications
• Rejuvenation of the immune system
• AI applications for drug discovery and biomarker development in aging research
01
Emerging therapeutic approaches promoting Longevity
The field of longevity is not limited to extending lifespan, but instead aims to extend health span. This notion has garnered increasing interest from the scientific, pharmaceutical and biotech communities in the last decade. Although our bodies are inherently equipped with regenerative and healing functions, these wear off or completely shut down with age, leading to onset of diseases ranging from neurodegeneration to cardio-metabolic and mental disorders.
WHAT ARE WE SOLVING FOR?
• New anti-senescence therapies - (e.g., immunomodulators or senomorphics, rather than senolytic)
• Novel Biomarkers for biological age of cells (e.g., biomarkers applicable to a longevity therapeutics
• Epigenetic profiling for age related indications and potential applications
• Stem cell therapy for age related indications
• Rejuvenation of the immune system
• AI applications for drug discovery and biomarker development in aging research
02
Emerging diagnostic and therapeutic strategies for female and male infertility
Infertility is a global issue affecting 15% of reproductive-aged couples worldwide according to the WHO. Infertility has many potential causes and involves the male and/or female reproductive systems. The science of fertility addresses prevention, diagnosis and treatment of the condition, targeting both primary infertility (the inability to generate a first pregnancy) and secondary infertility (the inability to generate a second pregnancy).
WHAT ARE WE SOLVING FOR?
• Novel mechanisms of action to treat inflammation-induced infertility
• Novel mechanisms of action to address ovarian aging
• Novel technologies to assess egg quality and predict implantation outcomes
• Novel mechanisms of action to treat endometriosis
• New therapeutic approaches for male infertility
• Treatments for infertility based on the alteration of reproductive tract microbiome
• Novel minimally invasive IVF technologies
JOIN THE JOURNEY
aMoon Explorer
Novel DNA and RNA editing approaches
Gene editing allows for precise genome manipulation aiming to achieve a better understanding of fundamental biological principles or a desirable clinical therapeutic effect. The breath of interventions is vast from correcting disease-causing mutations and adding therapeutic genes to removing deleterious sequences all together. Gene editing is being explored in a wide range of diseases and successful clinical milestones are slowly paving a path for more treatments and tools to enable the growth of this nascent field.
03
WHAT ARE WE SOLVING FOR?
• Development of novel, high efficiency, programmable nucleases for gene editing
• Development of novel, therapeutically relevant in-vivo editing platforms
• Novel platforms to edit/modify RNA with drug-like small molecules
• Engineering of new enzymes with RNA editing capabilities
03
Novel DNA and RNA editing approaches
Novel DNA and RNA editing approaches
Gene editing allows for precise genome manipulation aiming to achieve a better understanding of fundamental biological principles or a desirable clinical therapeutic effect. The breath of interventions is vast from correcting disease-causing mutations and adding therapeutic genes to removing deleterious sequences all together. Gene editing is being explored in a wide range of diseases and successful clinical milestones are slowly paving a path for more treatments and tools to enable the growth of this nascent field.
WHAT ARE WE SOLVING FOR?
• Development of novel, high efficiency, programmable nucleases for gene editing
• Development of novel, therapeutically relevant in-vivo editing platforms
• Novel platforms to edit/modify RNA with drug-like small molecules
• Engineering of new enzymes with RNA editing capabilities